CB-103, CAS 218457-67-1

CB-103, CAS 218457-67-1
Artikelnummer
CAY36293-1
Verpackungseinheit
1 g
Hersteller
Cayman Chemical

Verfügbarkeit: wird geladen...
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Formulation: A solid

Formal Name: 6-[4-(1,1-dimethylethyl)phenoxy]-3-pyridinamine

Purity: ≥95%

Formula Markup: C15H18N2O

Formula Weight: 242,3

Shelf life (days): 1460

CAS Number: 218457-67-1

Notes: CB-103 is an inhibitor of Notch signaling.{65226} It binds to the b-trefoil domain (BTD) of recombination signal binding protein for immunoglobulin kappa J region (RBPJ) and inhibits the assembly of the RBPJ-Notch intracellular domain (NICD) transcription complex. CB-103 inhibits ligand-induced Notch signaling in HeLa cells expressing mouse Notch1, -2, -3, or -4 (IC50s = 1.5, 0.9, 1.1, and 2.9 µM, respectively). It reduces expression of the Notch target genes HES1, MYC, and DTX1 in RPMI-8402 T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, CB-103 (25 mg/kg) reduces tumor volume and increases survival in an HCC-1187 mouse xenograft model.
Mehr Informationen
Artikelnummer CAY36293-1
Hersteller Cayman Chemical
Hersteller Artikelnummer 36293-1
Green Labware Nein
Verpackungseinheit 1 g
Mengeneinheit STK
Methode Reinstoffe
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