Davunetide (acetate)

Formulation: A solid

Formal Name: L-asparaginyl-L-alanyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-L-glutamine, acetate

Purity: ≥98%

Formula Markup: C36H60N10O12 • XC2H4O2

Formula Weight: 824,9

Shelf life (days): 1460

Notes: Davunetide is a neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP).{61972} It promotes tubulin assembly in a cell-free assay when used at a concentration of 1 fM.{61973} Davunetide (1 fM) protects against cytotoxicity induced by tetrodotoxin (Item Nos. 14963 / 14964), a peptide derived from amyloid-β (Aβ), or zinc in isolated neonatal cerebral cortical cells.{61972,61973} Intravitreal administration of davunetide (4 µl of a 100 µg/ml solution) inhibits increases in cleaved caspase-3 and decreases in Bcl-2 levels in retina isolated from streptozotocin-induced diabetic rats.{61974} It improves survival in a superoxide dismutase 1 mutant (SOD1G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS) when administered at 10 µg/animal.{61975} Davunetide prevents decreases in brain choline acetyltransferase (ChAT) activity and prevents memory deficits in the Morris water maze in an Apoe-/- mouse model of neurodegeneration.{61972}

• Artikelnummer: CAY35487-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35487-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe