ICEC0942 (hydrochloride), CAS 1805789-54-1

Formulation: A solid

Formal Name: (3R,4R)-4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-3-piperidinol, monohydrochloride

Purity: ≥95%

Formula Markup: C22H30N6O • HCl

Formula Weight: 431

Shelf life (days): 1460

CAS Number: 1805789-54-1

Notes: ICEC0942 is a cyclin-dependent kinase 7 (Cdk7) inhibitor (IC50 = 0.04 µM).{65585} It is selective for Cdk7 over Cdk1, -2, -4, -5, -6, and -9 (IC50s = 1.8, 0.62, 49, 9.4, 34, and 1.2 µM, respectively). ICEC0942 induces cell cycle arrest at the G2/M phase and apoptosis in HCT116 cells when used at concentrations of 1 and 10 µM. In vivo, ICEC0942 (100 mg/kg) reduces tumor growth in MCF-7 and HCT116 mouse xenograft models.

• Artikelnummer: CAY30997-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30997-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe