(−)-JQ1, CAS 1268524-71-5

Formulation: A crystalline solid

Formal Name: (6R) 4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 1,1-dimethylethyl ester

Purity: ≥98%

Formula Markup: C23H25ClN4O2S

Formula Weight: 457

Shelf life (days): 730

CAS Number: 1268524-71-5

Notes: The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. (±)-JQ1 displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains.{19044,28490} The (−)-JQ1 stereoisomer has no appreciable affinity to BET bromodomains, whereas enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively.{19044}

• Artikelnummer: CAY11232-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11232-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe