JTE-607, CAS 188791-09-5

Formulation: A solid

Formal Name: N-[3,5-dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine, ethyl ester, dihydrochloride

Purity: ≥98%

Formula Markup: C25H31Cl2N3O5 • 2HCl

Formula Weight: 597,4

Shelf life (days): 1460

CAS Number: 188791-09-5

Notes: JTE-607 is an inhibitor of inflammatory cytokine synthesis.{62807} It inhibits the production of TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively). JTE-607 binds to cleavage and polyadenylation-specific factor 3 (CPSF3), an enzyme involved in 3’-end processing of pre-mRNA, in cell-free assays and induces accumulation of CXCL8 pre-mRNA in LPS-stimulated SC cells.{62808} In vivo, JTE-607 (0.3-10 mg/kg, i.v.) reduces LPS-induced mortality in a C. parvum-sensitized mouse model of endotoxic shock.{62807}

• Artikelnummer: CAY36942-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36942-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe