Koumine, CAS 1358-76-5

Formulation: A solid

Formal Name: (3S,4S,4aR,6R,11bS,11cS)-11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-6,4-(epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole

Purity: ≥98%

Formula Markup: C20H22N2O

Formula Weight: 306,4

Shelf life (days): 1460

CAS Number: 1358-76-5

Notes: Koumine is an alkaloid that has been found in Gelsemium elegans and has diverse biological activities.{62600,62601,62602,62603} It inhibits the proliferation of MCF-7 breast cancer cells (IC50 = 124 µg/ml) as well as induces apoptosis and cell cycle arrest at the G2/M phase in the same cells.{62600} Koumine (200 and 400 µg/ml) reduces LPS-induced increases in inducible nitric oxide synthase (iNOS), IL-1β, IL-6, and TNF-α levels in RAW 264.7 macrophages.{62601} It inhibits acetic acid-induced writhing and formalin-induced paw licking and biting in mice when administered at doses of 2 and 10 mg/kg.{62602} Koumine (0.4-10 mg/kg) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.{62603}

• Artikelnummer: CAY36210-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36210-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe