Ku-55933, CAS 587871-26-9

Formulation: A crystalline solid

Formal Name: 2-​(4-​morpholinyl)​-​6-​(1-​thianthrenyl)​-4H-​pyran-​4-​one

Purity: ≥98%

Formula Markup: C21H17NO3S2

Formula Weight: 395,5

Shelf life (days): 1460

CAS Number: 587871-26-9

Notes: Ku-55933 is a potent ATP-competitive inhibitor of the ataxia-telangiectasia mutated (ATM) kinase (IC50 = 13 nM; Ki = 2.2 nM).{26647} Inhibition of ATM by Ku-55933 blocks radiation-induced phosphorylation of downstream cellular targets and sensitizes cells to the cytotoxic effects of both ionizing radiation and chemotherapeutic agents.{26647} Ku-55933 induces senescent breast, lung, and colon carcinoma cells to undergo cell death.{26648} It also inhibits HIV-1 replication in C8166 human T-lymophocyte cells with an IC50 value of 2.4 µM.{26649}

• Artikelnummer: CAY16336-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16336-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe