L-Pyroglutamic Acid, CAS 98-79-3

Formulation: A solid

Formal Name: 5-oxo-L-proline

Purity: ≥95%

Formula Markup: C5H7NO3

Formula Weight: 129,1

Shelf life (days): 1460

CAS Number: 98-79-3

Notes: L-Pyroglutamic acid is a cyclized form of L-glutamic acid (Item No. 30377). It is formed from L-glutamic acid or L-glutamine (Item No. 23716) by glutaminyl cyclase.{64496} A pyroglutamic acid-containing amyloid-β (Aβ) peptide (pGlu-Aβ (3-42)) aggregates at a higher rate than Aβ (3-42) and Aβ42 (Item No. 20574) when used at a concentration of 10 µM. It is a component of the neuropeptide adipokinetic hormone (AKH) in insects, a hormone that stimulates fatty acid oxidation during flight to provide energy.{64497} L-Pyroglutamic acid (500 mg/kg) increases the number of received shocks in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.{64498} Plasma levels of L-pyroglutamic acid are increased in patients with end-stage renal disease and pGlu-containing Aβ plaques have been found in brain tissue from patients with Alzheimer’s disease.{58132,64499} L-Pyroglutamic acid has been used in the synthesis of fibroblast activation protein (FAP) inhibitors.{58133}

• Artikelnummer: CAY36531-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36531-100
• Green Labware: Nein
• Verpackungseinheit: 100 g
• Mengeneinheit: STK
• Methode: Reinstoffe