Lefamulin, CAS 1061337-51-6

Formulation: A solid

Formal Name: 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-acetic acid, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester

Purity: ≥95%

Formula Markup: C28H45NO5S

Formula Weight: 507,7

Shelf life (days): 1460

CAS Number: 1061337-51-6

Notes: Lefamulin is a pleuromutilin antibiotic.{62722} It is active against methicillin-resistant S. aureus (MRSA), S. pyogenes, E. faecium, H. influenzae, M. catarrhalis, L. pneumonophilia, C. pneumoniae, and M. pneumoniae (MIC50s = 0.006-1 µg/ml). Lefamulin is also active against fluoroquinolone- and macrolide-resistant strains of N. gonorrhoeae (MIC90s = 1 mg/L for all). In vivo, lefamulin (10-40 mg/kg) reduces the number of colony-forming units (CFUs) in a mouse model of S. pneumoniae thigh infection.{62720} It also reduces LPS-induced production of TNF-α, IL-6, IL-1β, and GM-CSF, bronchoalveolar lavage fluid (BALF) neutrophil infiltration, and lung matrix metalloproteinase-9 (MMP-9) levels in a mouse model of LPS-induced neutrophilia.{62721} Formulations containing lefamulin have been used in the treatment of community-acquired bacterial pneumonia (CABP).

• Artikelnummer: CAY36285-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36285-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe