Formulation: A solid
Formal Name: 9-L-leucine-1-9-kallidin, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C47H75N13O11 • XCF3COOH
Formula Weight: 998,2
Shelf life (days): 1460
Notes: Lys-(Des-Arg9, Leu8)-Bradykinin is a bradykinin B1 receptor antagonist (Ki = 0.43 nM for the rabbit aorta receptor).{65251} It is selective for the bradykinin B1 over the B2 receptor (Ki = >10 µM for the rabbit ileum receptor).{65252} Lys-(Des-Arg9, Leu8)-Bradykinin inhibits contractions induced by the bradykinin B1 receptor agonist Des-Arg9-bradykinin (Item No. 31136) in isolated rabbit aortic rings (pA2 = 8.54).{65253} Intraperitoneal administration of Lys-(Des-Arg9, Leu8)-bradykinin (5 mg/kg per day for three days) reduces increases in paw edema in a rat model of arthritis induced by peptidoglycan-polysaccharide (PGPS).{65254}