1V209, CAS 1062444-54-5

Formulation: A solid

Formal Name: 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-benzoic acid

Purity: ≥98%

Formula Markup: C16H17N5O5

Formula Weight: 359,3

Shelf life (days): 1460

CAS Number: 1062444-54-5

Notes: 1V209 is a benzoic acid-modified purine that, when conjugated to polysaccharides or sterols, acts as a toll-like receptor 7 (TLR7) agonist.{69340,69341} A variety of 1V209-polysaccharide conjugates, but not 1V209 alone, increase TNF-α secretion from RAW 264.7 macrophages and IL-6 secretion from bone marrow-derived dendritic cells (BMDCs; EC50s = 4.62-61.7 and 3.2-188 nM, respectively). Liposomes encapsulating 1V209-cholesterol conjugates decrease primary tumor weight, secondary tumor volume, and the number of secondary lung metastases, as well as increase tumor-associated CD8+ IFN-γ+ T cells and survival, in a CT26 colorectal cancer mouse model of tumor rechallenge and lung metastasis.{69341}

• Artikelnummer: CAY38318-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38318-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe