2'(3')-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt)

Formulation: A solution in water

Formal Name: 2′(or 3′)-[2-(methylamino)benzoate] adenosine 5′-(trihydrogen diphosphate), trisodium salt

Purity: ≥95% (a mixture of isomers)

Formula Markup: C18H19N6O11P2 • 3Na

Formula Weight: 626,3

Shelf life (days): 730

Notes: 2'-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (2’-MANT-ADP) and 3’-MANT-ADP are fluorescent ADP derivatives, which undergo spontaneous isomerization.{67344} 2’(3’)-MANT-ADP selectively inhibits recombinant mammalian adenylyl cyclase 1 (AC1), AC2, AC5, and AC6 (Kis = 250, 1,500, 270, and 380 nM, respectively), bovine lung soluble guanylyl cyclase (sGC; Ki = 400 nM), and B. anthracis edema factor AC toxin (Ki = 450 nM) over rat testis soluble AC (sAC) and B. pertussis AC toxin (Kis = 15 and 18 µM, respectively). Formation of 2’(3’)-MANT-ADP from 2’(3’)-MANT-ATP (Item No. 38467) has been used to quantify the activity of the ATPase kinesin.{67358} A related derivative, 2'(3')-MANT-ATP (Item No. 38469), displays an emission maximum of 446 nm upon excitation at 350 nm.{67581}

• Artikelnummer: CAY38466
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38466-2.8
• Green Labware: Nein
• Verpackungseinheit: 2,8 mg
• Mengeneinheit: STK
• Methode: Reinstoffe, Fluorescence