2-Nonylquinolin-4(1H)-one-d4

Formulation: A solid

Formal Name: 2-nonyl-4(1H)-quinolinone-5,6,7,8-d4

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C18H21D4NO

Formula Weight: 275,4

Shelf life (days): 730

Notes: 2-Nonylquinolin-4(1H)-one-d4 is intended for use as an internal standard for the quantification of 2-nonylquinolin-4(1H)-one (Item No. 9003627) by GC- or LC-MS. 2-Nonylquinolin-4(1H)-one is a quinolone alkaloid that has been found in P. aeruginosa and has diverse biological activities.{58183},{58184},{58185},{58188} It reduces infection of Huh7.5 cells by hepatitis C virus (HCV) with an IC50 value of 1.4 µg/ml.{58183} 2-Nonylquinolin-4(1H)-one (50 and 100 µg/ml) is also active against L. gongylophorus, a symbiotic fungus of the agricultural pest A. sexdens (leaf-cutting ant).{58184} It inhibits activation of nuclear factor of activated T cells (NFAT) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and the calcium ionophore A23187 (Item No. 11016) in Jurkat cells (IC50 = 3.44 µM), but not LPS-induced NF-κB activation in RAW 264.7 cells (IC50 = >100 µM), in reporter assays.{58185}

• Artikelnummer: CAY9003970-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9003970-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung