Formulation: A solid
Purity: ≥98%
Formula Markup: C19H12N2O8
Formula Weight: 396,3
Shelf life (days): 1460
CAS Number: 173550-33-9
Notes: 3,5-Bis(4-nitrophenoxy)benzoic acid is a Notch1 signaling modulator.{62679,62680} It decreases the production of C-terminally elongated Notch1 amyloid-β-like peptide (Nβ25) from the full-length receptor, a marker of Notch1 intracellular domain release and transcription modification, in HEK293 cells.{62679} 3,5-Bis(4-nitrophenoxy)benzoic acid (50 µM) also decreases activation of the Notch1 target hes family bHLH transcription factor 1 (HES1) in a luciferase reporter assay using HCT116 cells.{62680}