Notes: 3-hydroxy-4-Methoxyphenethylamine is a metabolite of the catecholamine dopamine (Item Nos. 36532 / 21992).{66109} It is formed from dopamine by catechol-O-methyltransferase (COMT). 3-hydroxy-4-Methoxyphenethylamine (200 µM) decreases the viability of SH-SY5Y cells.{66110} It induces tachycardia and increases blood pressure in normotensive or DOCA-salt hypertensive rats when administered at a dose of 1 mg/kg.{66111} 3-hydroxy-4-Methoxyphenethylamine (100 mg/kg) induces tremors and rigidity in mice.{66112}