Formulation: A solid
Formal Name: 2-(5-hydroxy-1H-indol-3-yl-2,4,6,7-d4)acetic-2,2-d2 acid
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C10H3D6NO3
Formula Weight: 197,2
Shelf life (days): 1460
CAS Number: 2748469-82-9
Notes: 5-hydroxy Indole-3-acetic acid-d6 (5-HIAA-d6) is intended for use as an internal standard for the quantification of 5-HIAA (Item No. 22889) by GC- or LC-MS. 5-HIAA is a metabolite of the monoamine neurotransmitter serotonin (5-HT; Item No. 14332).{40084} It is formed from serotonin via a 5-hydroxy indole-3-acetaldehyde intermediate by aldehyde dehydrogenase. 5-HIAA has been used as a biomarker for the detection of neuroendocrine tumors. Brain levels of 5-HIAA are decreased in patients with severe Alzheimer’s disease.{69100}