6-Thioguanosine-5'-O-triphosphate (sodium salt)

Formulation: A solution in water

Formal Name: 6-thio-guanosine 5′-(tetrahydrogen triphosphate), tetrasodium salt

Purity: ≥98%

Formula Markup: C10H12N5O13P3S • 4Na

Formula Weight: 627,2

Shelf life (days): 780

Notes: 6-Thioguanosine-5’-O-triphosphate (6-thio-GTP) is an active metabolite of the purine analog 6-thioguanine (Item No. 15774) and the immunosuppressive purine analog azathioprine (Item No. 13987).{51291,51292} It is formed from 6-thioguanine via 6-thio-GMP and 6-thio-GDP intermediates by phosphorylation and from azathioprine via 6-mercaptopurine (Item No. 23675), 6-thio-GMP, and 6-thio-GDP intermediates by a non-enzymatic process and several enzymatic reactions. 6-thio-GTP binds to a variety of GTPases, including Rac, Ras, Cdc42, and RhoA but selectively inhibits activation of Rac1 and Rac2 over Cdc42 in primary human CD4+ T cells stimulated with anti-CD3 and anti-CD28 antibodies.{66376,66377} It inhibits T cell receptor-stimulated proliferation of T cells and reduces CD28-dependent T cell survival in vitro in isolated mouse splenocytes.{66378} 6-Thio-GTP (0.5 mg/kg) increases survival in a mouse model of heart transplantation.

• Artikelnummer: CAY38390
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38390-2.7
• Green Labware: Nein
• Verpackungseinheit: 2,7 mg
• Mengeneinheit: STK
• Methode: Reinstoffe