Formulation: A solid
Formal Name: 7-(methyl-d3)guanosine
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C11H12D3N5O5
Formula Weight: 300,3
Shelf life (days): 1460
Notes: 7-Methylguanosine-d3 is intended for use as an internal standard for the quantification of 7-methylguanosine (Item No. 15988) by GC- or LC-MS. 7-Methylguanosine is a methylated form of the purine nucleoside guanosine (Item No. 27702). It is an RNA modification that is present in the 5’-terminal cap of mRNA, where it promotes translation, as well as in tRNA, where it stabilizes the tRNA structure.{57941,57942} 7-Methylguanosine has been used as a substrate to measure the activity of purine nucleoside phosphorylase (PNP).{57943} Urinary 7-methylguanosine levels are decreased in patients with prostate cancer.{57941}