8-Chloroadenosine-5'-triphosphate (sodium salt), CAS 793671-47-3

Formulation: A solution in water

Formal Name: 8-chloro-adenosine 5′-(tetrahydrogen triphosphate), tetrasodium salt

Purity: ≥95%

Formula Markup: C10H11ClN5O13P3 • 4Na

Formula Weight: 629,6

Shelf life (days): 730

CAS Number: 793671-47-3

Notes: 8-Chloroadenosine-5’-triphosphate (8-chloro ATP) is an active metabolite of the anticancer agent 8-chloro cAMP and a derivative of the nucleotide adenosine 5’-triphosphate (ATP; Item No. 14498).{69006} It is formed from 8-chloro cAMP via 8-chloroadenosine (Item No. 35766) and mono- and diphosphate intermediates. 8-chloro ATP accumulates for up to 12 hours following application of 8-chloro cAMP or 8-chloroadenosine and is associated with inhibition of cell growth, decreases in endogenous ATP levels, and a reduction in RNA, but not DNA, synthesis in patient-derived multiple myeloma cells. It inhibits topoisomerase II-α-dependent relaxation of supercoiled pUC19 DNA when used at concentrations of 1.5 to 8 mM, as well as reduces topoisomerase II-α-catalyzed ATP hydrolysis by 50% at 1 mM, in K562 human myelocytic leukemia cells.{68366}

• Artikelnummer: CAY38448
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38448-2.7
• Green Labware: Nein
• Verpackungseinheit: 2,7 mg
• Mengeneinheit: STK
• Methode: Reinstoffe