AZD 5305, CAS 2589531-76-8

Formulation: A solid

Formal Name: 5-[4-[(7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methyl-2-pyridinecarboxamide

Purity: ≥98%

Formula Markup: C22H26N6O2

Formula Weight: 406,5

Shelf life (days): 1460

CAS Number: 2589531-76-8

Notes: AZD 5305 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1; IC50 = 0.003 µM).{69339} It is selective for PARP1 over PARP2, PARP3, PARP5a, and PARP6 (IC50s = 1.4, 3.4, >89, and 26 µM, respectively). AZD 5305 inhibits the proliferation of BRCA2-/- DLD-1 colorectal cancer cells (IC50 = 0.002 µM). It induces tumor regression in a patient-derived xenograft (PDX) mouse model of BRCA1 mutant triple-negative breast cancer (TNBC) when administered at doses ranging from 0.3 to 10 mg/kg.

• Artikelnummer: CAY37769-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37769-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe