Formulation: A solid
Formal Name: (2S,2′S)-N,N′-(1,4-piperazinediyldi-3,1-propanediyl)bis[2-amino-5-[(aminoiminomethyl)amino]-pentanamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C22H48N12O2 • XCF3COOH
Formula Weight: 512,7
Shelf life (days): 1460
Notes: Ciraparantag is an anticoagulant reversal agent.{66202,66203} It selectively binds to unfractionated heparin, enoxaparin, and Factor IXa (Kds = 28, 17, and 35 µM, respectively) over edoxaban (Item No. 24030), rivaroxaban (Item No. 16043), Factor Xa, Factor IX, thrombin (Item No. 13188), antithrombin, and fibrinogen, and only weakly binds to an enoxaparin-antithrombin complex and fondaparinux (Item No. 24033; Kds = 690 and 9,600 µM, respectively), in cell-free assays.{66202} Ciraparantag (200 µg/ml) prevents decreases in fibrin diameter induced by the Factor Xa inhibitor edoxaban in isolated human whole blood. It reduces edoxaban-, dabigatran-, apixaban-, rivaroxaban-, unfractionated heparin-, or enoxaparin-stimulated increases in tail transection-induced blood loss in rats.{66203}