Formulation: A solid
Formal Name: (12aR,24aR)-2,3,12a,13,14,15,24,24a-octahydro-5,6,17,18-tetramethoxy-1,13-dimethyl-8,11:20,23-dietheno-1H,12H-[1,10]dioxacyclooctadecino[2,3,4-ij:11,12,13-i'j′]diisoquinoline
Purity: ≥98%
Formula Markup: C38H42N2O6
Formula Weight: 622,8
Shelf life (days): 1460
CAS Number: 518-94-5
Notes: Cycleanine is an alkaloid that has been found in T. subcordata and has anticancer and antimalarial activities.{62698,62699} It selectively inhibits the growth of OVCAR-8, A2780, IGROV-1, and OVCAR-4 ovarian cancer cells (IC50s = 10, 7.6, 14, and 7.2 µM, respectively) over non-cancerous ovarian surface epithelial cells (IC50 = 35 µM).{62698} It also halts the cell cycle at the subG1 phase and induces apoptosis in OVCAR-8 cells. Cycleanine (25 and 50 mg/kg) reduces parasitemia and increases survival in a mouse model of infection with a chloroquine-resistant strain of P. berghei.{62699}