Notes: DL-Pyroglutamic acid is a cyclized form of glutamic acid that has been found in E. aureum and is a racemic mixture of the D-glutamate metabolite D-pyroglutamic acid (Item No. 31170) and the L-glutamate and L-glutamine metabolite L-pyroglutamic acid (Item No. 36531).{64807} A DL-pyroglutamic acid-magnesium complex decreases immobility time in the forced swim test and increases the latency to paw withdrawal in the hot plate test in rats.{64808} DL-Pyroglutamic acid has been used as a building block in the synthesis of GABA peptides with antinociceptive activity in rats.{64809} Plasma levels of D- and L-pyroglutamic acid are increased in patients with end-stage renal disease.{58132}