FTI-276 (trifluoroacetate salt), CAS 1217471-51-6

Formulation: A solid

Formal Name: N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1′-biphenyl]-2-yl]carbonyl]-L-methionine, 2,2,2-trifluoroacetate

Purity: ≥98%

Formula Markup: C21H27N3O3S2 • CF3COOH

Formula Weight: 547,6

Shelf life (days): 1460

CAS Number: 1217471-51-6

Notes: FTI-276 is a CAAX peptidomimetic inhibitor of farnesyltransferase (FTase; IC50 = 500 pM).{66344} It contains the C-terminal CAAX sequence, Cys-Val-Iso-Met (CVIM), of K-Ras4B, a form of Ras that is commonly mutated in human cancers, and is selective for FTase over geranylgeranyltransferase I (GGTase I; IC50 = 50 nM). It inhibits the growth of NIH3T3 cells expressing oncogenic farnesylated H-Ras (RasF), but not geranylgeranylated H-Ras (RasGG) or Raf, when used at a concentration of 20 µM.{66345} FTI-276 (50 mg/kg) also reduces tumor growth in a mouse xenograft model using Calu-1 cells that contain a K-Ras oncogenic mutation but not in a model using NCI H810 cells that do not contain a K-Ras mutation.

• Artikelnummer: CAY10011661-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10011661-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe