(±)-Linalool-d3, CAS 1216673-02-7

Formulation: A neat oil

Formal Name: 3,7-dimethyl-1,6-octadien-1,1,2-d3-3-ol

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C10H15D3O

Formula Weight: 157,3

Shelf life (days): 1460

CAS Number: 1216673-02-7

Notes: (±)-Linalool-d3 is intended for use as an internal standard for the quantification of (±)-linalool (Item No. 21575) by GC- or LC-MS. (±)-Linalool is a monoterpene alcohol that has been found in C. sativa, C. indica, and hemp with diverse biological activities.{41453,21575,36770,36771,36772,42327} It induces cell cycle arrest at the G0/G1 and G2M phase in U937 and HeLa cells, respectively.{21575} (±)-Linalool is cytotoxic to U937 and HeLa cells (IC50s = 2.59 and 11.02 μM, respectively). It induces recruitment of a PGC-1α coactivator peptide to the PPARα ligand binding domain (EC50 = 5.45 μM in a TR-FRET assay).{36770} In vivo, (±)-linalool reduces plasma triglyceride concentration in mice fed a Western diet and transgenic mice expressing human ApoE2, but not PPARα-/- mice. It has molluscicidal and larvicidal effects in vitro (LC50s = 0.25 and 0.07 mg/L for O. hupensis and S. japonicium, respectively), and it reduces the amount of schistosomulum recovered from mouse skin after S. japonicium challenge infection.{36771} (±)-Linalool (10-40 mg/kg) reduces the number of macrophages and neutrophils, as well as the production of TNF-α, IL-6, IL-1β, IL-8, and MCP-1, in bronchoalveolar lavage fluid (BALF) in a mouse model of cigarette smoke-induced acute lung inflammation.{36772} It also decreases immobility time in the forced swim test in mice, indicating antidepressant-like activity.{42327}

• Artikelnummer: CAY9004273-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9004273-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung