Mecillinam, CAS 32887-01-7

Formulation: A crystalline solid

Formal Name: (2S,5R,6R)-6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Purity: ≥95%

Formula Markup: C15H23N3O3S

Formula Weight: 325,4

Shelf life (days): 1460

CAS Number: 32887-01-7

Notes: Mecillinam is a β-lactam antibiotic.{52100} It is active against Gram-negative bacteria, including E. coli, K. pneumoniae, and N. gonorrhoeae (MIC90s = 4, 8, and 1 μg/ml, respectively). It is also active against clinical isolates of E. coli, K. pneumoniae, and P. mirabilis isolated from human urine.{52102} It binds to K. pneumoniae penicillin-binding protein 2 (PBP2) over PBP1A/B, PBP3, PBP4, and PBP5/6 (IC50s = 256, 128, >256, and >256 mg/L, respectively) in a competitive binding assay.{52101} Mecillinam is efficacious against susceptible E. coli strains in a systemic mouse model of infection with 50% protective dose (PD50) values ranging from less than or equal to 0.39 to 6.4 mg/kg.{52103}

• Artikelnummer: CAY9002008-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9002008-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK
• Methode: Reinstoffe