MSAB, CAS 173436-66-3

Formulation: A solid

Formal Name: 3-[[(4-methylphenyl)sulfonyl]amino]-benzoic acid, methyl ester

Purity: ≥98%

Formula Markup: C15H15NO4S

Formula Weight: 305,3

Shelf life (days): 1460

CAS Number: 173436-66-3

Notes: MSAB is an inhibitor of Wnt/β-catenin signaling.{64960} It binds to β-catenin and promotes its proteasomal degradation in HCT116 cells. MSAB (2-10 µM) selectively inhibits the proliferation of Wnt-dependent cancer cells over non-cancerous cells and Wnt-independent cancer cells. It reduces Wnt3a-induced increases in β-catenin levels in a reporter assay using HEK293T cells. MSAB decreases the expression of the Wnt target genes AXIN2, MYC, CCND1, and BMP4 in a concentration-dependent manner in HCT116 cells. It reduces tumor growth and increases intratumoral apoptosis in Wnt-dependent HCT116, HT115, and H23 mouse xenograft models when administered at doses of 10 and 20 mg/kg.

• Artikelnummer: CAY36497-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36497-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK
• Methode: Reinstoffe