Formulation: A solid
Formal Name: 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1′-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-pyrano[2,3-c]pyrazole-5-carbonitrile
Purity: ≥98%
Formula Markup: C24H24N4O2
Formula Weight: 400,5
Shelf life (days): 1460
CAS Number: 2146095-85-2
Notes: SHIN 1 is an inhibitor of serine hydroxymethyltransferase 1 (SHMT1) and SHMT2 (IC50s = 5 and 13 nM, respectively).{66156} It inhibits proliferation of H1299 non-small cell lung cancer (NSCLC) cells overexpressing the proto-oncogene FRAT1 (IC50 = 0.6 µM). SHIN 1 decreases tumor volume in an NSCLC mouse xenograft model using FRAT1-overexpressing H1299 cells when administered at a dose of 100 mg/kg three times a week.