Supinoxin, CAS 888478-45-3

Formulation: A solid

Formal Name: 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxy-2-quinoxalinyl)-1-piperazinecarboxamide

Purity: ≥98%

Formula Markup: C22H24FN5O4

Formula Weight: 441,5

Shelf life (days): 1460

CAS Number: 888478-45-3

Notes: Supinoxin is an inhibitor of Y593-phosphorylated DEAD-box helicase 5 (DDX5).{67366} It binds to Y593-phosphorylated DDX5 (Kd = ~19 nM), but does not interact with unphosphorylated DDX5, and selectively inhibits β-catenin-dependent ATPase activity over RNA-dependent ATPase activity at 0.2 µM. Supinoxin induces apoptosis in MDA-MB-231 cells (IC50 = 12 nM) and inhibits cell growth in SK-MEL-28 cells (IC50 = 20 nM).

• Artikelnummer: CAY36573-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36573-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe