Formulation: A solid
Formal Name: N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide
Purity: ≥98%
Formula Markup: C17H19FN2O2S
Formula Weight: 334,4
Shelf life (days): 1460
CAS Number: 875927-64-3
Notes: UoS 12258 is a positive allosteric modulator of AMPA receptors.{68091} It potentiates glutamate-induced currents in HEK293 cells expressing human ionotropic glutamate receptor 2 (GluR2) homomeric AMPA receptors (EC50 = 2.51 µM), as well as HEK293 cells expressing GluR1, GluR3, or GluR4 homomeric AMPA receptors. UoS 12258 (0.3 and 1 mg/kg) increases novel object exploration in a novel object recognition test in rats. It also reduces escape latencies in the Morris water maze in aged rats.