Verdiperstat, CAS 890655-80-8

Formulation: A solid

Formal Name: 1,2,3,5-tetrahydro-1-[2-(1-methylethoxy)ethyl]-2-thioxo-4H-pyrrolo[3,2-d]pyrimidin-4-one

Purity: ≥98%

Formula Markup: C11H15N3O2S

Formula Weight: 253,3

Shelf life (days): 1460

CAS Number: 890655-80-8

Notes: Verdiperstat is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 630 nM), a redox enzyme involved in oxidative stress.{69284} It is selective for MPO over a panel of 130 enzymes, transporters, and ion channels (IC50s = >50 µM for all).{69285} Oral administration of verdiperstat (180 µmol/kg) reduces MPO expression, prevents an increase in neuronal loss, and prevents decreases in motor score and stride length in a PLP-αSYN transgenic mouse model of multiple system atrophy, a neurological disorder characterized by motor neuron degeneration and α-synuclein aggregation in the brain.{69285}

• Artikelnummer: CAY37333-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37333-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe