Formulation: A solid
Formal Name: 2,6-dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol
Purity: ≥98%
Formula Markup: C16H13Br2N3O3
Formula Weight: 455,1
Shelf life (days): 1460
CAS Number: 211555-05-4
Notes: WHI-P97 is an inhibitor of JAK3 (IC50 = 11 µM).{16507} It inhibits leukotriene C4 (LTC4) and LTB4 release, mediated by the high-affinity IgE receptor Fc ε receptor I (FcεRI), from RBL-2H3 mast cells when used at a concentration of 10 µM.{65556} It also inhibits FcεRI-mediated 5-lipoxygease (5-LO) translocation to the membrane in RBL-2H3 mast cells. In vivo, WHI-P97 (40 mg/kg) reduces antigen-induced LTC4 production in IgE-sensitized mice. It also reduces airway hyperresponsiveness and bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a mouse model of ovalbumin-induced allergic asthma when administered at doses of 12 and 40 mg/kg.