WHI-P97, CAS 211555-05-4

Formulation: A solid

Formal Name: 2,6-dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol

Purity: ≥98%

Formula Markup: C16H13Br2N3O3

Formula Weight: 455,1

Shelf life (days): 1460

CAS Number: 211555-05-4

Notes: WHI-P97 is an inhibitor of JAK3 (IC50 = 11 µM).{16507} It inhibits leukotriene C4 (LTC4) and LTB4 release, mediated by the high-affinity IgE receptor Fc ε receptor I (FcεRI), from RBL-2H3 mast cells when used at a concentration of 10 µM.{65556} It also inhibits FcεRI-mediated 5-lipoxygease (5-LO) translocation to the membrane in RBL-2H3 mast cells. In vivo, WHI-P97 (40 mg/kg) reduces antigen-induced LTC4 production in IgE-sensitized mice. It also reduces airway hyperresponsiveness and bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a mouse model of ovalbumin-induced allergic asthma when administered at doses of 12 and 40 mg/kg.

• Artikelnummer: CAY36385-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36385-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe