MK-4827 (tosylate), CAS 1038915-73-9

Formulation: A crystalline solid

Formal Name: 2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide, 4-methylbenzenesulfonate

Purity: ≥98%

Formula Markup: C19H20N4O • C7H8O3S

Formula Weight: 492,6

Shelf life (days): 1460

CAS Number: 1038915-73-9

Notes: MK-4827 is an orally bioavailable inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 3.8 and 2.1 nM, respectively).{34138} It inhibits the proliferation of cancer cells carrying the breast cancer mutations BRCA1 and BRCA2 in vitro (IC50 values range from 10-100 nM) and has efficacy alone against a xenograft of BRCA1-deficient cancer in mice.{34138,20554} MK-4827 sensitizes human lung and breast cancer xenografts to radiation in mice.{34140} Formulations containing MK-4827 are effective against ovarian cancer, particularly in platinum-sensitive, recurrent ovarian cancer.{34139}

• Artikelnummer: CAY20842-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20842-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK
• Methode: Reinstoffe