ML-351, CAS 847163-28-4

Formulation: A crystalline solid

Formal Name: 5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile

Purity: ≥98%

Formula Markup: C15H11N3O

Formula Weight: 249,3

Shelf life (days): 1460

CAS Number: 847163-28-4

Notes: Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{3140} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{12192} ML-351 is an inhibitor of human reticulocyte 15-LO-1 (IC50 = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2.{29406,26085} ML-351 was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.{29406,26085}

• Artikelnummer: CAY16119-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16119-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe