Nicotinamide riboside-d4 (triflate)

Formulation: A solid (hygroscopic)

Formal Name: 3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-2,4,5,6-d4, trifluoromethanesulfonate

Purity: ≥95%

Formula Markup: C11H11D4N2O5 • CF3SO3

Formula Weight: 408,3

Shelf life (days): 1460

Notes: Nicotinamide riboside-d4 is intended for use as an internal standard for the quantification of nicotinamide riboside (Item No. 23132) by GC- or LC-MS. Nicotinamide riboside is a riboside form of nicotinamide (Item No. 11127) that is found in trace amounts in yeast-containing and milk-derived products.{38460} It is a precursor of NAD+ (Item No. 16077) and a source of vitamin B3 (niacin). Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells when used at concentrations ranging from 1-1,000 μM.{38461} It also decreases acetylation of FOXO1 and SOD2, which are substrates of sirtuin 1 (SIRT1) and SIRT3, respectively, but not the SIRT2 substrate tubulin, indicating nicotinamide riboside selectively enhances SIRT1 and SIRT3 deacetylase activity. Nicotinamide riboside (400 mg/kg per day) increases NAD+ levels in liver and skeletal muscle and prevents body weight gain in mice fed a high-fat diet. It also increases NAD+ in the cerebral cortex and reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.{38462}

• Artikelnummer: CAY34311-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34311-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung