Noscapine (hydrochloride), CAS 912-60-7

Formulation: A crystalline solid

Formal Name: (3S)-6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone, monohydrochloride

Purity: ≥98%

Formula Markup: C22H23NO7 • HCl

Formula Weight: 449,9

Shelf life (days): 1460

CAS Number: 912-60-7

Notes: Noscapine is an alkaloid that has been found in opium and has anticancer and antitussive properties.{28232,28233,49588} It binds to tubulin and induces cell cycle arrest at the G2/M phase in HeLa cells when used at a concentration of 20 µM.{28233} Noscapine induces apoptosis in HeLa cells and thymocytes (IC50s = 25 and 10 µM, respectively) and reduces proliferation of MCF-7 breast and Renal 1983 bladder cancer cells (IC50s = 42.3 and 39.1 µM, respectively). In vivo, noscapine (120 mg/kg) induces tumor regression in an MCF-7 mouse xenograft model. Noscapine (30 and 70 mg/kg) decreases the number of citric acid-induced coughs in guinea pigs.{49588}

• Artikelnummer: CAY17255-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17255-5
• Green Labware: Nein
• Verpackungseinheit: 5 g
• Mengeneinheit: STK
• Methode: Reinstoffe