Notes: Pranoprofen-13C-d3 is intended for use as an internal standard for the quantification of pranoprofen (Item No. 17875) by GC- or LC-MS. Pranoprofen is a non-steroidal anti-inflammatory drug (NSAID) and COX-1 inhibitor (IC50 = 3.1 µM).{62590,29081} It decreases B. pertussis-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated rat peritoneal leukocytes (IC50 = 0.39 µM).{29081} Ocular application of pranoprofen reduces corneal epithelial damage in a mouse model of corneal alkali burns.{62590}