QN523, CAS 878581-60-3

Formulation: A crystalline solid

Formal Name: N-8-quinolinyl-2-pyrazinecarboxamide

Purity: ≥98%

Formula Markup: C14H10N4O

Formula Weight: 250,3

Shelf life (days): 730

CAS Number: 878581-60-3

Notes: QN523 is an anticancer agent.{65310} It is cytotoxic to MiaPaCa-2, PANC-1, and BxPC-3 pancreatic cancer cells (IC50s = 0.11, 0.5, and 3.3 µM, respectively). QN523 (0.5 µM) induces cell cycle arrest at the S phase in MiaPaCa-2 cells. It increases levels of the endoplasmic reticulum (ER) stress markers glucose-regulated protein 78 kDa (GRP78), DNA damage inducible transcript 3 (DDIT3), activating transcription factor 3 (ATF3), and growth differentiation factor 15 (GDF15), as well as the autophagy markers WD repeat domain phosphoinositide-interacting protein 1 (WIPI1), GABAA receptor-associated protein-like 1 (GABARAPL1), and LC3-II in MiaPaCa-2 cells in a concentration-dependent manner. QN523 reduces tumor volume in a MiaPaCa-2 mouse xenograft model.

• Artikelnummer: CAY37123-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37123-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe