Rimiducid, CAS 195514-63-7

Formulation: A solid

Formal Name: 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylic acid, (2S,2'S)-2,2'-[1,2-ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] ester

Purity: ≥90%

Formula Markup: C78H98N4O20

Formula Weight: 1411,6

Shelf life (days): 1460

CAS Number: 195514-63-7

Notes: Rimiducid is a chemical inducer of dimerization (CID) for fusion proteins of the FK506 binding protein (FKBP) mutant FKBPF36V.{62854} It selectively binds to FKBPF36V over wild-type FKBP (IC50s = 0.005 and >10 µM, respectively). Rimiducid induces apoptosis in HT-1080 fibrosarcoma cells expressing a FKBPF36V fusion protein with the intracellular domain of Fas, also known as CD95, that contains a myristoylation sequence (EC50 = ~0.1 nM). It also induces apoptosis in primary human T lymphocytes expressing a FKBPF36V-Fas fusion protein (IC50 = ~0.2 nM).{62855} Rimiducid decreases serum human growth hormone (hGH) levels in mice injected with HT-1080 cells expressing FKBPF36V-Fas that constitutively secrete hGH, indicating conditional cell ablation (ED50 = 0.4 mg/kg).{62854}

• Artikelnummer: CAY35303-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35303-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe