Trigonelline-d3 (chloride)

Formulation: A solid

Formal Name: 3-carboxy-1-(methyl-d3)-pyridinium, monochloride

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C7H5D3NO2 • Cl

Formula Weight: 176,6

Shelf life (days): 1460

Notes: Trigonelline-d3 is intended for use as an internal standard for the quantification of trigonelline (Item No. 11904) by GC- or LC-MS. Trigonelline is an alkaloid that has been found in L. japonicus and an active metabolite of niacin that has diverse biological activities.{66006,66009,66007,66008} It increases levels of the brown fat marker proteins PRDM16, PGC-1α, and UCP1 in 3T3-L1 adipocytes when used at a concentration of 75 µM.{66006} Trigonelline inhibits degranulation of, and decreases the production of IL-6 and TNF-α in, activated primary mouse bone marrow mast cells (BMMCs).{66009} In vivo, trigonelline (200 mg/kg) reduces serum IgE levels, pulmonary immune cell infiltration, and mucus secretion in a mouse model of ovalbumin-induced allergic asthma. It reduces serum levels of IL-1β, IL-6, IL-18, and malondialdehyde (MDA) and renal cell apoptosis, as well as increases protein levels of peroxisome proliferator-activated receptor γ (PPARγ) in a rat model of high-fat diet- and streptozotocin-induced type 2 diabetic nephropathy when administered at a dose of 40 mg/kg.{66007} Trigonelline (50 mg/kg) reduces hepatic de novo lipogenesis, induces hepatic autophagy, and prevents weight gain, insulin resistance, and hepatic steatosis in a mouse model of high-cholesterol and high-fat diet-induced non-alcoholic fatty liver disease (NAFLD).{66008}

• Artikelnummer: CAY36340-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36340-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung