Tubercidin, CAS 69-33-0

Formulation: A solid

Formal Name: 7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Purity: ≥98%

Formula Markup: C11H14N4O4

Formula Weight: 266,3

Shelf life (days): 1460

CAS Number: 69-33-0

Notes: Tubercidin is a nucleoside analog that has been found in S. tubercidicus and has diverse biological activities.{64535,64536,64537,64538} It is active against S. faecalis (IC50 = 0.02 µM) and cytotoxic to P388 murine leukemia and A549 human lung adenocarcinoma cells (IC50s = 0.008 and 0.019 µg/ml, respectively).{64535,64536} Tubercidin reduces infection of Calu-3 cells by severe acute respiratory coronavirus 2 (SARS-CoV-2; EC50 = 0.05 µM) but is toxic to A549 cells expressing human ACE2 (A549-ACE2) and Vero cells.{64537} Tubercidin (5 mg/kg per day), in combination with the nucleoside transport inhibitor prodrug NBMPR-P, increases survival in a mouse model of schistosomiasis but is hepato- and nephrotoxic and induces mortality when administered alone at the same dose for four days.{64538}

• Artikelnummer: CAY35834-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35834-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe