(Z)-PUGNAc, CAS 132489-69-1

Formulation: A crystalline solid

Formal Name: (1Z)-δ-lactone-2-(acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-D-gluconimidic acid

Purity: ≥95%

Formula Markup: C15H19N3O7

Formula Weight: 353,3

Shelf life (days): 1460

CAS Number: 132489-69-1

Notes: Proteins can be modified post-translationally by the addition of O-linked N-acetylglucosamine (O-GlcNAc). Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a β-N-acetylglucosaminidase that removes GlcNAc from O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that reversibly inhibits NCOAT (Ki = 40-110 nM).{28217,28220} It also less potently inhibits other hexosaminidases and exochitinases.{28220,28219,17016} (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both in vitro and in cells.{28218}

• Artikelnummer: CAY17151-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17151-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe