2H-Cho-Arg (trifluoroacetate salt), CAS 1609010-59-4

Formulation: A solution in ethanol

Formal Name: (3β)-[6-[[(2S)-2-amino-(5α)-[(aminoiminomethyl)amino]-1-oxopentyl]amino]hexanoate], cholestan-3-ol, bis(2,2,2-trifluoroacetate)

Purity: ≥95%

Formula Markup: C39H73N5O3 • 2CF3COO

Formula Weight: 886,1

Shelf life (days): 365

CAS Number: 1609010-59-4

Notes: 2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.{44005} It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin (Item No. 21633) and the caveolae-mediated endocytosis inhibitor genistein (Item No. 10005167), but not by inhibitors of clathrin- or micropinocytosis-mediated endocytosis. It induces cytotoxicity in H1299 cells (IC50 = 92.7 μg/ml).

• Artikelnummer: CAY25944-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25944-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK