306-O12B-3, CAS 2982842-90-8

Formulation: A solution in methyl acetate

Formal Name: bis(2-(octyldisulfaneyl)ethyl) 3,3'-((4-methyl-11-oxo-12-oxa-15,16-dithia-4,8-diazatetracosyl)azanediyl)dipropionate

Purity: ≥95%

Formula Markup: C46H91N3O6S6

Formula Weight: 974,6

Shelf life (days): 730

CAS Number: 2982842-90-8

Notes: 306-O12B-3 is an ionizable cationic lipidoid.{66155} It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of antisense oligonucleotides (ASOs). LNPs containing 306-O12B-3 localize to the liver after intravenous administration in mice. LNPs containing 306-O12B-3 in combination with other lipids encapsulating ASOs targeting the gene encoding proprotein convertase subtilisin kexin type 9 (PCSK9) decrease hepatic PCSK9 expression in mice. Intravenous administration of LNPs containing 306-O12B-3 and the cationic lipidoid NT1-O14B (Item No. 37095) encapsulating ASOs against tau decreases tau expression and levels in mouse brain.{68120}

• Artikelnummer: CAY37096-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37096-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe