Formulation: A solution in ethanol
Formal Name: tetra(decan-2-yl) 3,3',3'',3'''-((piperazine-1,4-diylbis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate
Purity: ≥95%
Formula Markup: C62H120N4O8
Formula Weight: 1049,7
Shelf life (days): 1460
Notes: 4-O10b1 is an ionizable cationic lipid (pKa = 5.148) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vitro and in vivo.{51936} LNPs containing 4-O10b1, conjugated to an antibody targeting the mouse macrophage marker F4/80 (anti-F4/80), and encapsulating siRNA targeting the mRNA encoding TGF-β-activated kinase 1 (Tak1) inhibit poly(I:C)-induced production of IL-1β, IL-6, and TNF-α in RAW 264.7 macrophages. In vivo, intranasal administration of these LNPs decreases lung injury and reduces total protein levels and myeloperoxidase (Mpo) activity in bronchoalveolar lavage fluid (BALF) in a mouse model of influenza A-induced pneumonia.
Deutsch
English
