Notes: C10-200 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.{69788} LNPs containing C10-200 and encapsulating mRNA encoding a luciferase reporter selectively induce luminescence in the livers of mice to a greater extent than LNPs containing the branched-chain ionizable cationic lipidoid C12-200 (Item No. 36699). LNPs containing C10-200 and encapsulating mRNA encoding erythropoietin (EPO) increase serum levels of EPO in mice.