Formulation: A solution in ethanol
Formal Name: N,N-dimethyl-2,2-di-(9Z,12Z)-9,12-octadecadien-1-yl-1,3-dioxolane-4-ethanamine
Purity: ≥98%
Formula Markup: C43H79NO2
Formula Weight: 642,1
Shelf life (days): 730
CAS Number: 1190197-97-7
Notes: DLin-KC2-DMA is an ionizable cationic amino lipid (apparent pKa = 6.7) that has been used in combination with other lipids in the formation of lipid nanoparticles.{62187} Administration of Factor VII siRNA in DLin-KC2-DMA-containing LNPs reduces serum Factor VII protein levels in mice. LNPs containing DLin-KC2-DMA and androgen receptor siRNA decrease serum prostate-specific antigen (PSA) and tumor androgen receptor protein levels in an LNCaP mouse xenograft model.{62188}