1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-PC, CAS 1287795-07-6

Formulation: A crystalline solid

Formal Name: (7R)-7-[3-[(3S,4S)-9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-phorbinyl]-1-oxopropoxy]-4-hydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphapentacosan-1-aminium, 4-oxide, inner salt

Purity: ≥90%

Formula Markup: C57H82N5O9P

Formula Weight: 1012,3

Shelf life (days): 730

CAS Number: 1287795-07-6

Notes: 1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC is a phospholipid-porphyrin conjugate that is composed of phosphatidylcholine containing palmitic acid (Item No. 10006627) at the sn-1 position and the photosensitizer pyropheophorbide a (Item No. 21371) at the sn-2 position.{69312} Lipid nanoparticles (LNPs) containing 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC and encapsulating FAM-labeled siRNA are dissociated under irradiation with near-infrared light (NIR) in PC3-Luc6 cells. 1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC then enters the endolysosomal membrane and generates reactive oxygen species (ROS), which disrupt the membrane and allow the release of FAM-labeled siRNA into the cytosol. 1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC-stabilized nanoemulsions loaded with the mitotic inhibitor paclitaxel (Item No. 10461), combined with laser irradiation, reduce tumor growth and increase survival in a KB squamous cell carcinoma mouse xenograft model.{69313}

• Artikelnummer: CAY38430-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38430-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe