4A3-SCC-10

Formulation: A solution in ethanol

Formal Name: ((methylazanediyl)bis(propane-3,1-diyl))bis(8,14-dioxo-7,15-dioxa-3,4,18,19-tetrathia-11-azahenicosane-11,1,21-triyl) tetrakis(3-(decylthio)-2-methylpropanoate)

Purity: ≥90%

Formula Markup: C91H171N3O16S12

Formula Weight: 1948,1

Shelf life (days): 720

Notes: 4A3-SCC-10 is a disulfide bond-containing biodegradable ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.{66842} LNPs containing 4A3-SCC-10 and encapsulating a Cy5-RNA reporter have improved endosomal escape ability over Cy5-RNA-encapsulated LNPs containing 4A3-SC-10, which does not contain disulfide bonds, in HeLa cells. Intravenous administration of LNPs containing 4A3-SCC-10 and encapsulating an mRNA luciferase reporter selectively accumulate in mouse liver.

• Artikelnummer: CAY41276-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41276-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK